Treatment Antibiotics For infants with various high risk factors clinical indications of infection. abnormal wBc. antibiotic therapy should be institute immediately without wait Initial empirical treatment: ampicillin and an aminoglycoside(gentamicin or amikacin) ototoxicity! Nosocomial in NICU: nafcillin or Vancomycin Change according to drug sensitivity test Third-generation cephalosporins(eg Cefotaxime) Duration: 7-10 days, or 5-7 days after response 14 days for meningitis >A negative blood culture result does not preclude bacterial infection Supportive Care: energy, liquid, maintain organ functionTreatment ➢ Antibiotics • For infants with various high risk factors, clinical indications of infection, abnormal WBC, antibiotic therapy should be institute immediately without wait. • Initial empirical treatment: ampicillin and an aminoglycoside (gentamicin or amikacin) ototoxicity! • Nosocomial in NICU: nafcillin or Vancomycin • Change according to drug sensitivity test • Third-generation cephalosporins (eg Cefotaxime) ➢ Duration: 7~10 days, or 5~7 days after response, 14 days for meningitis ➢ A negative blood culture result does not preclude bacterial infection ➢ Supportive Care: energy, liquid, maintain organ function