Risk factors High blood pressure, high Ldl cholesterol, and smoking are key heart disease risk factors for heart disease. about half of americans( 49%)have at least one of these three risk factors Several other medical conditions and lifestyle choices can also put people at a higher risk for heart disease, Including: Diabetes Overweight and obesity Poor diet Physical inactivity Excessive alcohol useHigh blood pressure, high LDL cholesterol, and smoking are key heart disease risk factors for heart disease. About half of Americans (49%) have at least one of these three risk factors. Several other medical conditions and lifestyle choices can also put people at a higher risk for heart disease, including: Diabetes Overweight and obesity Poor diet Physical inactivity Excessive alcohol use Risk Factors