E Cri du chat syndrome: 5p deletion B 11. Which of the following is a false statement? A Francis Galton discovered that many quantitative traits such as height, weight, and IQ have normal(Gaussian) distributions in human populations B. Francis Galton discovered that the average heights of children of tall or short parents tend toequal the average heights of the parents C"Regression to the mean"describes the tendency for inherited quantitative traits to shift toward the population mean(average) D. Francis Galton was unaware of the discoveries of Gregor Mendel E. Francis Galton imagined the physical substrate for inherited traits to be fluid-like, rather than comprising discrete factors that inherited unchanged from generation to generation B12. Which of the following is an incorrect matching between the named family relationship and the percentage of shared(autosomal)DNA? A. brother and sister: 50% B. first-cousins: 25% C. father and daughter: 50% D grandmother and grandson: 25% E. great-grand father and great-grandson: 12.5% C13. Which of the following is a false statement? A. Nonsense-mediated decay protects cells from the accumulation of mutant proteins B Incorrectly spliced mRNAs are often eliminated via the nonsense-mediated decay thy C Indels within the 3-untranslated region (3 -UTR) are likely to trigger mRNA degradation via nonsense-med iated decay D Coding region Indels comprising numbers of nucleotides that are not evenly divided by 3 are likely to trigger mRNA degradation via nonsense-mediated decay E. Non-sense mediated decay of mRNA encoding rate - limiting enzymes is often the mechanism underlying diseases caused by haploinsufficiency B14. Which of the following genetic diseases in not caused by expansion of a triplet repeat? A Huntingtons disease B. AlZheimer's disease C Fragile X disease D. MyotonIc dystrophy C Friedreich ataxia E15. Which of the following statements is false? A Relative risk for family members is defined as ratio of: i)the prevalence of a disease among family members who share the same percentage of dna with a proband to ii) the prevalence ofthe disease in the general populationE. Cri du Chat syndrome: 5p deletion B 11.Which of the following is a false statement? A.Francis Galton discovered that many quantitative traits such as height, weight, and IQ have normal (Gaussian) distributions in human populations. B. Francis Galton discovered that the average heights of children of tall or short parents tend toequal the average heights of the parents. C. “Regression to the mean" describes the tendency for inherited quantitative traits to shift toward the population mean (average). D.Francis Galton was unaware of the discoveries of Gregor Mendel. E.Francis Galton imagined the physical substrate for inherited traits to be “fluid-like,” rather than comprising discrete factors that inherited unchanged from generation to generation. B12. Which of the following is an incorrect matching between the named family relationship and the percentage of shared (autosomal) DNA? A. brother and sister: 50% B. first-cousins: 25% C. father and daughter: 50% D.grandmother and grandson: 25% E. great-grandfather and great-grandson: 12.5% C13.Which of the following is a false statement? A. Nonsense-mediated decay protects cells from the accumulation of mutant proteins. B. Incorrectly spliced mRNAs are often eliminated via the nonsense-mediated decay pathway. C. Indels within the 3’-untranslated region (3’-UTR) are likely to trigger mRNA degradation via nonsense-mediated decay. D.Coding region Indels comprising numbers of nucleotides that are not evenly divided by 3 are likely to trigger mRNA degradation via nonsense-mediated decay. E. Non-sense mediated decay of mRNA encoding rate-limiting enzymes is often the mechanism underlying diseases caused by haploinsufficiency. B14. Which of the following genetic diseases in not caused by expansion of a triplet repeat? A. Huntington’s disease B.Alzheimer’s disease C.Fragile X disease D. Myotonic dystrophy C.Friedreich ataxia E15. Which of the following statements is false? A.Relative risk for family members is defined as ratio of: i) the prevalence of a disease among family members who share the same percentage of DNA with a proband to ii) the prevalence ofthe disease in the general population