LOBAL INITIATIVE FOR Definition VCOBSTRUCTIVE LUNG DISY The airflow limitation is usually progressive and associated with the chronic inflammatory response of the lung to noxious particles or gases. Acute exacerbations and other complications influence the severity of the disease. Definition • The airflow limitation is usually progressive and associated with the chronic inflammatory response of the lung to noxious particles or gases. • Acute exacerbations and other complications influence the severity of the disease