Medical Genetics DISORDERS WITH INCREASED SUSCEPTIBILITY TO UNUSUAL INFECTIONS Type of Disorder Conditions Disorder Conditions Circulatory Sickle cell disease, diabetes Primary X-linked gammaglobulin nd sys mellitus, nephrosis, vari- immuno- emia, DiGeorge anomaly, temic cose veins, congenital deficien chronic granulomatous disorders cardiac defects CIes disease, C3 deficiency Obstructive Ureteral or urethral stenosis, Unusual Antibiotic overgrowth. disorders bronchial asthma. bron. micro chronic infections with chiectasis, allergic rhiniti biologic resistant organism, contin blocked eustachian tubes factors uous reinfection(contami- cystic fibrosis ited water suppl tegu- Eczema, burTis, skull frac infectious contact con- mentary tures. midline sinus tracts aminated inhalation ther defects ciliary abnormalities apy equipment) Secondary Malnutrition, prematurity Foreign Ventricular shunts, central immuno lymphoma, splenectomy, bodies venous catheter, artificial deficien. uremia, immunosuppress heart valves, urinary cath cies sive therapy, protein- eter, aspirated foreign losing enteropathy bodies chronic viral diseasesMedical Genetics DISORDERS WITH INCREASED SUSCEPTIBILITY TO UNUSUAL INFECTIONS