BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering Toda Applications of hydrogels in bioengineering Covalent hydrogels structure and chemistry of biomedical gels Thermodynamics of hydrogel swelling Readin N.A. Peppas et aL., "Physicochemical foundations and structural design of hydrogels in medicine and biology, Annu. Rev. Biomed Eng, 2, 9-29(2000) Supplementary Reading: P.J. Flory, Principles of Polymer Chemistry, Cornell University Press, Ithaca, pp 464 469, pp. 576-581 Statistical thermodynamics of networks and network swelling) Applications of hydrogels in bioengineering Hydrogels: insoluble network of polymer chains that swell in aqueous solutions Gels can be classified by the type of crosslinker Covalent covalent junctions Physical non-covalent junctions Lecture 7-Hydrogels 1 1of15BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering Today: Applications of hydrogels in bioengineering Covalent hydrogels structure and chemistry of biomedical gels Thermodynamics of hydrogel swelling Reading: N.A. Peppas et al., ‘Physicochemical foundations and structural design of hydrogels in medicine and biology,’ Annu. Rev. Biomed. Eng., 2, 9-29 (2000). Supplementary Reading: P.J. Flory, ‘Principles of Polymer Chemistry,’ Cornell University Press, Ithaca, pp. 464- 469, pp. 576-581 (Statistical thermodynamics of networks and network swelling) Applications of hydrogels in bioengineering • Hydrogels: insoluble network of polymer chains that swell in aqueous solutions • Gels can be classified by the type of crosslinker:1 • Covalent - covalent junctions • Physical - non-covalent junctions Lecture 7 – Hydrogels 1 1 of 15