Contents Contents Acknowledgements Introduction Background Use of the publication 1. General considerations 1.1 Definition 1.2 Need for evaluation 1.3 Evaluation methodology 1.5 Availability and practicability 1.6 Studies on therapeutic mechanisms 6 1.7 Selection of clinical trial reports 2. Review of clinical trial report 2.1 Pair 9 Head and face 9 Biliary and renal colic Traumatic or postoperative pain... Dentistry 2.2 Infections 2.3 Neurological disorders 12 2.4R 2.5 Digestive disorders 14 2. 6 Blood disorders 15 2.7 Urogenital disorders 2.8 Gynaecological and obstetric disordersContents Contents Acknowledgements ...............................................................................................iii Contents ........................................................................................................... v Introduction............................................................................................................ 1 Background........................................................................................................ 1 Objectives .......................................................................................................... 2 Use of the publication ........................................................................................ 2 1. General considerations .................................................................................. 3 1.1 Definition.................................................................................................. 3 1.2 Need for evaluation ................................................................................. 3 1.3 Evaluation methodology .......................................................................... 3 1.4 Safety ...................................................................................................... 5 1.5 Availability and practicability.................................................................... 5 1.6 Studies on therapeutic mechanisms........................................................ 6 1.7 Selection of clinical trial reports ............................................................... 7 2. Review of clinical trial reports............................................................................ 9 2.1 Pain ......................................................................................................... 9 Head and face.................................................................................................... 9 Locomotor system.............................................................................................. 9 Gout.................................................................................................................. 10 Biliary and renal colic ....................................................................................... 10 Traumatic or postoperative pain ...................................................................... 11 Dentistry ........................................................................................................... 11 Childbirth .......................................................................................................... 11 Surgery............................................................................................................. 11 2.2 Infections ............................................................................................... 12 2.3 Neurological disorders........................................................................... 12 2.4 Respiratory disorders............................................................................. 14 2.5 Digestive disorders ................................................................................ 14 2.6 Blood disorders...................................................................................... 15 2.7 Urogenital disorders............................................................................... 15 2.8 Gynaecological and obstetric disorders................................................. 16 v