PATHOGENESIS OF FEVER Antigens HYPOTHALAMUS Antigen antibody lymphocyte complex Bacteria and Prostaglandin E bacterial products m Endogenous Increase in body pyrogens temperature -(interleukin 1) set point (Tumor necrosis factor) Viruses (Interferon a) Heat generation Mononuclear Heat conservation phagocyte Crystals (eg. urate) FeverPATHOGENESIS OF FEVER