1)cause and pathogenesis excessive loss of water and sodium replaced with water only vomiting, diarrhea; burn; diuretics; Addison's disease (ADS+); chronic renal failure; renal tubular acidosis 2)adaptive response and effect on body O movement of body fluid ECF- ICF cellular swelling Blood volume↓ Extracellular fluid↓ Shock dehydrated signs edema of brain and lung1) cause and Pathogenesis excessive loss of water and sodium replaced with water only. vomiting, diarrhea; burn; diuretics; Addison’s disease (ADS ) ; chronic renal failure; renal tubular acidosis 2) adaptive response and effect on body ① movement of body fluid ECF ICF cellular swelling Blood volume Extracellular fluid Shock dehydrated signs edema of brain and lung