> Mucosal mechanoreceptors V Puffs of nitrogen gas on the mucosal induce C-Fos expression in ipan blocked by ttX Unaffected by hexamethonium(六甲铵), the nicotinic receptor antagonist Y Mostly indirect, through the release of 5-HT from enterochromaffin cells(肠嗜铬细胞) in the mucous membrane 粘膜)12 ➢Mucosal mechanoreceptors: ✓Puffs of nitrogen gas on the mucosal induce C-Fos expression in IPAN ▪Blocked by TTX ▪Unaffected by hexamethonium (六甲铵), the nicotinic receptor antagonist ✓Mostly indirect, through the release of 5-HT from enterochromaffin cells (肠嗜铬细胞) in the mucous membrane (粘膜)