Outside of Asia,the handshake is most common and most meaningful physical contact you will have with a business colleague,of course,not everyone shakes hands alike and not all variations are deliberate.Still analyzing a colleague's handshake after the fact may provide some clues into his or her character and intentions. This is,by nature,a rather inexact science.Some handshake basics.Outside of Asia, the handshake is most common and most meaningful physical contact you will have with a business colleague, of course, not everyone shakes hands alike and not all variations are deliberate. Still, analyzing a colleague’s handshake after the fact may provide some clues into his or her character and intentions. This is, by nature, a rather inexact science. Some handshake basics: