Unit5:疾病预后证据的分析评价 主讲教师：胡予 助理教师：王伟 一、教学目的 掌握和熟悉预后评价的概念和方法 二、教学内容 复习和强化循证医学的概念 掌握预后的概念，掌握预后的评价以及循证的过程： 3 学会设计有关预后的研究。 三、教学重点和难点：预后评价的各项标准，预后研究设计中的关键点。 四、中文和英文关键词 Prognosis,critical appraisal,evidence based medicine, 五、作业与思考 ■Assignment 1: Read the refe erenc article by Larpacis A etal try to understand the principles about prognosis. ■Assignment2: Read the article by H.Klar Yaggi et al. Obstructive Sleep Apnea asa Risk Factor for Stroke and Death ing ques tions: What is the study design? 2.a)What is the study population? b)How did the author select the study population? c)Is your case similar to the study population? 3. a)How is the OSA defined?(How is the exposure defined?) b)Does the author provide a clear description of the stage of OSA? 4. Was follow up sufficiently long and complete? a)How is the follow up period defined? b)Any loss to follow up? rtant pr rognostic factors? umeWere obiective and unbiased oumrfr 6 b)How do they get the outcomes? c)How were the outcomes ascertained? 7. What are the results? a)Ex:What is the chance ofa 60-year-old,obese,Caucasian male with OSA still alive in five years? 8. Potential biases a)Are there any selection bias?Referral bias? b)Can you see any potential for misclassification of exposure? c)Can you see any potential for misclassification of outcome?Unit 5：疾病预后证据的分析评价 主讲教师：胡予 助理教师：王伟 一、教学目的 掌握和熟悉预后评价的概念和方法 二、教学内容 1. 复习和强化循证医学的概念； 2. 掌握预后的概念，掌握预后的评价以及循证的过程； 3. 学会设计有关预后的研究。 三、教学重点和难点：预后评价的各项标准，预后研究设计中的关键点。 四、中文和英文关键词 Prognosis, critical appraisal, evidence based medicine, 五、作业与思考  Assignment 1: Read the reference article by Larpacis A et al. User’s Guides to the medical literature V. How to use an article about prognosis, and try to understand the principles about prognosis.  Assignment 2: Read the article by H. Klar Yaggi et al. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death Answer the following questions: 1. What is the study design? 2. a) What is the study population? b) How did the author select the study population? c) Is your case similar to the study population? 3. a) How is the OSA defined? (How is the exposure defined?) b) Does the author provide a clear description of the stage of OSA? 4. Was follow up sufficiently long and complete? a) How is the follow up period defined? b) Any loss to follow up? 5. Was there adjustment for important prognostic factors? 6. a) What were the outcomes? Were objective and unbiased outcome criteria used? b) How do they get the outcomes? c) How were the outcomes ascertained? 7. What are the results? a) Ex: What is the chance of a 60-year-old, obese, Caucasian male with OSA still alive in five years? 8. Potential biases a) Are there any selection bias? Referral bias? b) Can you see any potential for misclassification of exposure? c) Can you see any potential for misclassification of outcome?