BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 · Alpha helix,beta non- cooperative interactions Unstable, no gelation cooperative interactions sheet Stable interactions, gel forms General characteristics of physical gel biomaterials o Dehydration of hydrophobes/hydrophobic association PEO-b-PPo-b-PEO, PPo-b-PEO-b-PPo(commercially known as Pluronics(BASF)) o Similar associative properties from PLGA-PEG-PLGA copolymers and PE PLGA-PEG copolymers 粥 Example blocks: Poly(ethylene glycol)(PEG) CHCH Hydrophilic B blocks Hydrophobic A blocks 。 CoacH R Poly(propylene oxide)(PPO Poly(butylene oxide)(PBO) Lecture 8 sical gels 20f12BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 8 – Physical gels 2 of 12 • Alpha helix, beta sheet non-cooperative interactions: cooperative interactions: Unstable, no gelation Stable interactions, gel forms General characteristics of physical gel biomaterials o Dehydration of hydrophobes/hydrophobic association o Examples: • PEO-b-PPO-b-PEO, PPO-b-PEO-b-PPO (commercially known as Pluronics (BASF)) 2 o Similar associative properties from PLGA-PEG-PLGA copolymers and PEG￾PLGA-PEG copolymers water Hydrophilic B blocks Hydrophobic A blocks Poly(propylene oxide) (PPO) Poly(butylene oxide) (PBO) Poly(ethylene glycol) (PEG) Example blocks: CH3O CH3 O O O HO-(CH-C-O-CH-C-O-)x-(CH2-C-O-CH2-C-O)y-(CH2-CH2-O)z￾PLGA CH3O CH3 O O O (CH-C-O-CH-C-O-)x-(CH2-C-O-CH2-C-O)y-H PEG PLGA PEO PPO PEO