The induced conformational change in hexokinase M11.8 D-glucose (a)Before glucose binding (b)After glucose binding Induced fit is the main model for changes in the enzyme to fit the transition state and to bring functional side groups of the enzyme to the right location to help the catalysis. The induced conformational change in hexokinase M11.8 Induced fit is the main model for changes in the enzyme to fit the transition state and to bring functional side groups of the enzyme to the right location to help the catalysis