Conservation of the metabolic core The average core enzyme in E coli H. pylori has orthologs in 71.7%o of the 32 reference bacteria. While the noncore enzymes have an 55 evolutionary retention of only 47.70 This difference is not a simple 63 consequence of the high-lethality fraction of the core enzymes 18 Random selection of 90 enzymes with a 74. 7o lethality ratio has an average evolutionary retetion of E. coli s, cerevisiae Maintaining the core s integrity is a collective need of the organismConservation of the metabolic core ◼ The average core enzyme in E. coli has orthologs in 71.7% of the 32 reference bacteria. While the noncore enzymes have an evolutionary retention of only 47.7%. ◼ This difference is not a simple consequence of the high-lethality fraction of the core enzymes. ◼ Random selection of 90 enzymes with a 74.7% lethality ratio has an average evolutionary retetion of only 63.4% Maintaining the core’s integrity is a collective need of the organism