Background co Mortalin: molecular chaperon located primaril Accumulation of in the mitochondria for mitochondrial oxidative mitochondrial homeostasis stress and abnormal proteins= impaired 6 PD= Parkin gene mutation dopaminergicneurons reduced levels of mortalin in brain regions of PD 4 Parkin genes function: patients activates self-repair mechanism in the mitochondriaBackground Accumulation of mitochondrial oxidative stress and abnormal proteins= impaired dopaminergic neurons Parkin gene’s function: activates self-repair mechanism in the mitochondria Mortalin: molecular chaperon located primarily in the mitochondria for mitochondrial homeostasis PD= Parkin gene mutation + reduced levels of mortalin in brain regions of PD patients