Pathogenesis The mechanism of action ◆BZD In the CNS benzodiazepines exert their clinical effect by enhancing the activity of the inhibitory neurotransmitter gaba he clinical effects of gaba release and GABa-gated chloride channels include sleep induction and excitement inhibition) ◆ Barbiturates in prolongation of the duration of opening of GABA-gated Chloride channels, leading to hyperpolarization of the membrane and suppression of neurotransmission ◆NBNB similar to the action of barbiturates BZD In the CNS, benzodiazepines exert their clinical effect by enhancing the activity of the inhibitory neurotransmitter GABA. (The clinical effects of GABA release and GABA-gated chloride channels include sleep induction and excitement inhibition)  Barbiturates in prolongation of the duration of opening of GABA-gated chloride channels, leading to hyperpolarization of the membrane and suppression of neurotransmission. 。 NBNB similar to the action of Barbiturates 二、 The mechanism of action Pathogenesis