武汉大子博卦踞褶 抗体药物现状 1900 Paul Ehrlich proposed side-chain theory, 1959 models for Gerald Edelman 1990 antibody-antigen binding& Rodney Porter published Antibody 2004 the molecular structure engineering of antibodies Bevacizumab technology (VEGF-A) 2014 Ramucirumab 1798 1948 1973 Edward jenner Astrid Fagraeus First atomic demonstrates first described role of plasma resolution structure Trastuzumab/2009* (VEGFR2 1998 smallpox vaccination B cells in antibody of an antibod (HER2 Ofatumumab generation fragment published (CD20) 1972 1774 1901 Gerald Edelman 2005 ady M Emil von Behr Rodney porter 1997 Cetuximab 2015 Wortley, Emanuel received Nobel awarded Nobel Rituximab Secukinumab Timoni, James Prize Prize (CD20) (EGFR) (11-17a) Pylarini pioneered concept of 1957 2001 smallpox Alemtuzumab inoculation Frank Burnet David 2012 aimag velope 1975 CD52) Pertuzumab the clonal selection Georges Kohler (HER2) Cesar Milstein 1890 invent hybridoma Emil von Behring technology Shibasaburo Kitasato show serum transfer from immunized animals could cure diptheria approved mAbs抗体药物现状