Targets for Immunosuppressant Drugs Costimulatory Antigenic Antigen-Presenting Cell Signal Signal -Cell Receptor IL-2 Receptor Ca2+ Cyclosporine曰b日 IL-2 Sirolimus Tacrolimus Purine Synthesis Activated Calcineurin NFAT-P Mycophenolate Mofetil TCell Cell Nuclear Factor of Activated T Cells Steroid Cycle Azathioprine (NFAT) Interleukin-2(IL-2)Gene Promoter Denton et al.Lancet.1999;353:1083-1091.Shanghai Jiao Tong University