遗传因素重要文献 We identified strong evidence of associations between PCOS and three loci:2p16.3 (rs13405728;combined P-value by meta-analysis. Pmeta=7.55×10-21,odds ratio(OR)0.71);2p21(rs13429458, Pmeta=1.73×10-23,OR0.67);and9q33.3(rs2479106,Pmeta 8.12 X 10-19,OR 1.34).These findings provide new insight into the. pathogenesis of PCOS.Follow-up studies of the candidate genes in these regions are recommendedWe identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis Pmeta = 7.55 × 10−21, odds ratio (OR) 0.71); 2p21 (rs13429458, Pmeta = 1.73 × 10−23, OR 0.67); and 9q33.3 (rs2479106, Pmeta = 8.12 × 10−19, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. 遗传因素--重要文献