2014-18 AVP Collecting duct principal cell or Blood Side AVP secretion mosmol/kg. AQP4 blood volume and blood pressure. Nonosmotic stimul: nausea, intracerebral angiotensin Il, serotonin, and multiple drugs Half-life in the circulation 10-20 min antidiuretic hormone(ADH) Response to Changes in Serum Osmolality AVP rine osmolality AVP secretion: systemic osmolality, threshold level of 285 S5mAximally effective osmol/kg. vasopressin levels blood volume and blood pressure. Nonosmotic stimul: nausea, intracerebral angiotensin Il, serotonin, and multiple drugs 80284288290294296 erum osmolality (mOsm/) Hypovolemia or hypotension Hyponatremia Plasma sodium concentration less than 135 Hypervolemia The most frequently encountered electrolyte 2602702802903003103203303402014-1-8 4 AVP • AVP secretion: – systemic osmolality, threshold level of 285 mosmol/kg. – blood volume and blood pressure. • Nonosmotic stimul: nausea, intracerebral angiotensin II, serotonin, and multiple drugs. • Half-life in the circulation: 10–20 min AVP • AVP secretion: – systemic osmolality, threshold level of 285 mosmol/kg. – blood volume and blood pressure. • Nonosmotic stimul: nausea, intracerebral angiotensin II, serotonin, and multiple drugs. • Half-life in the circulation: 10–20 min Hyponatremia • Plasma sodium concentration less than 135 mmol/L, • The most frequently encountered electrolyte abnormality in hospitalized patients