Clinical---History The pattern of symptoms in untreated gout changes over time. The attacks become more polyarticular. Although m ore joints may become involved, inflammation in a given j oint may become less intense. More proximal and upper. extremity joints become involved. Attacks occur more freq uently and last longer Eventually, patients may develop chronic polyarticular art hritis. Patients with gout are profoundly more likely to dev elop renal stones 浙医二院9 浙医二院 Clinical---History The pattern of symptoms in untreated gout changes over time. The attacks become more polyarticular. Although m ore joints may become involved, inflammation in a given j oint may become less intense. More proximal and upper￾extremity joints become involved. Attacks occur more freq uently and last longer. Eventually, patients may develop chronic polyarticular art hritis. Patients with gout are profoundly more likely to dev elop renal stones