Shige∥/ a Dysentery 1. Gram-negative bacillus does not ferment lactose nonmotile 2. Induces ruffling of host cells; once internalized, escapes to the cytoplasm a)Moves through the cytoplasm and spreads from cell to cell by polymerizing actin b)Accelerates cell death, forming plaques of necrotic cells c) Induces marked inflammation and rarely invades the bloodstreamShigella Dysentery 1. Gram-negative bacillus, does not ferment lactose, nonmotile. 2. Induces ruffling of host cells; once internalized, escapes to the cytoplasm. a) Moves through the cytoplasm and spreads from cell to cell by polymerizing actin. b) Accelerates cell death, forming plaques of necrotic cells. c) Induces marked inflammation and rarely invades the bloodstream. 16