国生 国生 Advantages of the aerosol ·Absorb quickly Disadvantages of the aerosol .Minimum contamination ·Expensive ·Improve stability ·Cooling effect Convenient to use Avoid first pass metabolism in GIT and liver Patient coordination ·Accurate dose Suitable for local or systemic agents .Non-invasive;Patient friendly 国生一 国生 ④Classification ④Classification Based on the dispersion systems Based on the administration route ·Solution aerosols(溶液型气雾剂) ,Inhalation aerosols(吸入气雾剂) ·Suspension aerosols(混悬型气雾剂) ·Non-inhalation aerosols(非吸入气雾剂)：dermal,, nasal,vaginal,rectal ·Emulsion aerosols(乳剂型气雾剂) ·Space aerosol(空间气雾 Based on the phase of the components ·Two phases aerosols(二相气雾剂) Based on the working way of valve ·Metered dose aerosols(定量气雾剂 ·Three phases aerosols(三相气雾剂 ·Non-metered dose aerosols(非定量气雾剂) 国丝生 国生 Metered dose inhaler Propellant is responsible for developing the proper ·Propellants抛射剂 pressure within the container,and it expels the product when the valve is opened and aids in the Product concentrate atomization or foam production of the product. ·Container ·Valve 33 Shanghai Jiao Tong University Advantages of the aerosol • Absorb quickly • Minimum contamination • Improve stability • Convenient to use • Avoid first pass metabolism in GIT and liver • Accurate dose • Suitable for local or systemic agents • Non-invasive; Patient friendly Shanghai Jiao Tong University Disadvantages of the aerosol • Expensive • Cooling effect • Patient coordination Shanghai Jiao Tong University Classification • Based on the dispersion systems • Solution aerosols (溶液型气雾剂) • Suspension aerosols (混悬型气雾剂) • Emulsion aerosols (乳剂型气雾剂) • Based on the phase of the components • Two phases aerosols (二相气雾剂) • Three phases aerosols (三相气雾剂) Shanghai Jiao Tong University Classification • Based on the administration route • Inhalation aerosols (吸入气雾剂) • Non-inhalation aerosols (非吸入气雾剂) : dermal, nasal, vaginal, rectal • Space aerosol (空间气雾剂) • Based on the working way of valve • Metered dose aerosols (定量气雾剂) • Non-metered dose aerosols (非定量气雾剂) Shanghai Jiao Tong University Metered dose inhaler • Propellants 抛射剂 • Product concentrate • Container • Valve Shanghai Jiao Tong University Propellant is responsible for developing the proper pressure within the container, and it expels the product when the valve is opened and aids in the atomization or foam production of the product