Add TFO GENE TFO nVn plate (antisense) strand Sense DNA strand mRNA Add antisense 5′ AAAAAA 3 5 AAAA 3 oligodeoxynucleotide or an antisense gene which is transcribed to give a (a) Inhibition of translation specific antisense RNA or (b)( If a ribozyme, direct cleavage a ribozyme of mRNA ( b)(i) If an oligodeoxynucleotide the mRNA of the RNA-DNA hybrid is cleaved by RNase H16