Activation of the Complement System All 3 activation pathways result in generation of an enzyme complex which can cleave C3, called the C3 convertase. C3->C3a C3b Integration point of the complement system (Innate and Adaptive immunity) Major amplification pointActivation of the Complement System All 3 activation pathways result in generation of an enzyme complex which can cleave C3, called the C3 convertase. C3 → C3a + C3b - Integration point of the complement system (Innate and Adaptive immunity) - Major amplification point