疾病 药物 无反应率 抑郁 SSRIs. SNRIs, TCAs 40-60% 哮喘 B-adrenergics LTD4 4-75% 糖尿病 Sulfony urea, Biguanides, 50-75% Glitazones 肿瘤(乳腺癌肺癌) Various 70-100% 群体治疗 有效无效 Are we treating sub-populations From Kalow, Tyndale & Meyer, Pharmacogenomics, 2010有效 无效 群体治疗 疾病 药物 无反应率 抑郁 SSRIs, SNRIs, TCAs 40-60% 哮喘 ß-adrenergics, LTD4 4-75% 糖尿病 Sulfonylurea, Biguanides, Glitazones 50-75% 肿瘤 (乳腺癌 肺癌) Various 70-100% ？ From Kalow, Tyndale & Meyer, Pharmacogenomics, 2010 Are we treating sub-populations?