History and development of Endocrinology(2) Work over the next several decades by biochemists physiologists, and clinical investigators led to the characterization of many hormones secreted into the blood stream from discrete glands or other organs These investigators showed for the first time that diseases such as hypothyroidism and diabetes could be treated successfully by replacing specific hormones These initial triumphs formed the foundation of the clinical specialty of endocrinology3 Work over the next several decades by biochemists, physiologists, and clinical investigators led to the characterization of many hormones secreted into the blood stream from discrete glands or other organs. These investigators showed for the first time that diseases such as hypothyroidism and diabetes could be treated successfully by replacing specific hormones. These initial triumphs formed the foundation of the clinical specialty of endocrinology. History and development of Endocrinology (2)