9/15/2016 Multi-dimensional View of Pathogenicity ·ex acquire genes,evolve ·Sense portal of entry ·Switch gene regulation ·Swim find a tissue to colonize. penetrate mucus ·Stick prevent removal from tissues Scavenge siderophores-iron nutrients Survive oxidatative-phagocytes,acid- stress stomach,heat-fever Multi-dimensional View of Pathogenicity ·Stealth avoid the immune system Strike back damage host tissues Subvert alter cytoskeleton and cell signaling,prevent phagocytosis or induce uptake ·Spread find other tissues Scatter exit the host and find another host-evolve 5 9/15/2016 5 Multi-dimensional View of Pathogenicity • Sex acquire genes, evolve • Sense portal of entry • Switch gene regulation • Swim find a tissue to colonize, penetrate mucus • Stick prevent removal from tissues • Scavenge siderophores-iron nutrients • Survive oxidatative-phagocytes, acid￾stress stomach, heat-fever Multi-dimensional View of Pathogenicity • Stealth avoid the immune system • Strike back damage host tissues • Subvert alter cytoskeleton and cell signaling, prevent phagocytosis or induce uptake • Spread find other tissues • Scatter exit the host and find another host- evolve