Medical Genetics Down syndrome Phenotype: The hand are short and broad,often with a single transverse palmar crease (simian crease); Congenital heart disease in at least 1/3 liveborn infants; 15-fold increase in the risk of leukemia; ●Alzheimer disease; ●Incidence:1/800. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more informationThis document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information