Functions of cytoplasmic matrix: The protein synthesis, degradation and modification. 8 hsp70 discard by hsp70 machiner hsp60-like hsp60-like machinery machinery ribosome correctly folded protein correctly folded protein Cells carefully monitor the amount of misfolded proteins. An accumulation of misfolded proteins in the cytosol triggers a heat shock response, which stimulates the transcription of genes encoding cytosolic chaperones that help to refold the proteinsFunctions of cytoplasmic matrix: The protein synthesis, degradation and modification. Cells carefully monitor the amount of misfolded proteins. An accumulation of misfolded proteins in the cytosol triggers a heat￾shock response, which stimulates the transcription of genes encoding cytosolic chaperones that help to refold the proteins