NE synthesis in nerve terminals and turnover 1 SYNTHESIS OF NH2 NOREPINEPHRINE CH.C-COOH he rate-limiting step 2 UPTAKE INTO STORAGE VESICLES H Inactive 4 e Dopamine entera vesicle L-Tyrosine e Norepinephrine is protected Tyrosine hydroxylase om degradation in erin, o Transport into vesicle is HO Inactive HO CH2C-COOH L-DOPA 3 RELEASE OF NEUROTRANSMITTER DOPA decarboxylase coll membrane ( Pyridoxal phosphate) e Release blocked by HO HO 5 REMOVAL OF NOREPINEPHRINE Dopamine rapidly taken into neuron Dopamine B-hydroxylase cocaine and imlpram (Ascorbate, O) 4 BINDING TO RECEPTOR of neurotransmitter 一CHCH2NH2 SYNAPTIC Norepinephrine 6 METABOLISM SPACE Catecholamine Biosynthetic Pathway mIne oxidase INTRACELLULAR RESPONSENE synthesis in nerve terminals and turnover Catecholamine Biosynthetic Pathway 4