D. A. Evans Rules for Ring Closure: Introduction Chem 206 Useful Literature Reviews http://www.courses.fasharvardedu/-chem206/ Johnson, C D (1993). " Stereoelectronic effects in the formation of 5- and 6-membered rings: the role of Baldwin's rules Acc. chem. Res. 26: 476-82 Beak, P (1992). " Determinations of transition-state geometries by the endocyclic restriction test: mechanisms of substitution at Chemistry 206 nonstereogenic atoms. Acc. Chem. Res 25: 215 Advanced organic Chemistry The Primary Literature Idwin, Chem. Soc. Chem. Comm. 1976. 734. 736 aldwin J. Chem. Soc. Chem. Comm. 1977 323 Baldwin, J. Org Chem 1977, 42, 3846 Lecture number 3 Baldwin, Tetrahedron 1982. 38 2939 Stereoelectronic Effects-2 Rules for Ring Closure: Baldwin's Rules i Problems of the Day Propose mechanisms for the following reactions Kirby, "Stereoelectronic Effects"Chapters 4, 5 NH2-NH Matthew d shair September 23, 2002D. A. Evans Chem 206 Useful LIterature Reviews ■ Problems of the Day Chemistry 206 Advanced Organic Chemistry Lecture Number 3 Stereoelectronic Effects-2 Matthew D. Shair Monday, September 23, 2002 http://www.courses.fas.harvard.edu/~chem206/ Rules for Ring Closure: Introduction Johnson, C. D. (1993). “Stereoelectronic effects in the formation of 5- and 6-membered rings: the role of Baldwin's rules.” Acc. Chem. Res. 26: 476-82. Beak, P. (1992). “Determinations of transition-state geometries by the endocyclic restriction test: mechanisms of substitution at nonstereogenic atoms.” Acc. Chem. Res. 25: 215. The Primary Literature "Rules for Ring Closure: Baldwin's Rules" Propose mechanisms for the following reactions O O R R HO HO O R R + H + Baldwin, J. Chem. Soc., Chem. Comm. 1976, 734, 736. Baldwin, J. Chem. Soc., Chem. Comm. 1977 323. Baldwin, J. Org. Chem. 1977, 42, 3846. Baldwin, Tetrahedron 1982, 38, 2939. Me OMe O NH2–NH2 HN NH Me O Kirby, "Stereoelectronic Effects" Chapters 4, 5