Practical implications I The core enzvmes may prove effective antibiotic targets a Currently used antibiotics Fosfomycin and cycloserine inhibit cell-wall peptidoglycan Sulfonamides and trimethoprim inhibit tetrahydrofolte biosvnthesis a Both pathways are present in H. pylori and E coliPractical implications ◼ The core enzymes may prove effective antibiotic targets. ◼ Currently used antibiotics: ◼ Fosfomycin and cycloserine inhibit cell-wall peptidoglycan. ◼ Sulfonamides and trimethoprim inhibit tetrahydrofolte biosynthesis. ◼ Both pathways are present in H. pylori and E. coli