SCIENCE DIRECT LUMINESCENCE ELSEVIER Journal of Luminescence 119-120(2006)132-136 www.elsevier.comple Infrared absorption of human breast tissues in vitro Chenglin Liu.b, Yuan Zhang, Xiaohui Yan, Xinyi Zhang C,, Chengxiang Li Wentao Yang, Daren Shi Department of Physics, Surface Physics Laboratory( National Key laboratory ) Synchrotre ation Research Center Fudan Unirersity, Shanghai 200433, China Physics Department of Yancheng Teachers'College, Yancheng 224002, China Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203, China d National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, china "Cancer Hospital, Medical Center, Fudan University, Shanghai 200032, China Available online 7 February 2006 Abstract The spectral characteristics of human breast tissues in normal status and during different cancerous stages have been investigated by synchrotron radiation based Fourier transform infrared(SR-FTIR) absorption spectroscopy. Thanks to the excellent synchrotron radiation infrared (IR)source, higher resolving power is achieved in SR-FTIR absorption spectra than in conventional IR absorption measurements. Obvious variations in IR absorption spectrum of breast tissues were found as they change from healthy to diseased, or say in progression to cancer. On the other hand, some pecific absorption peaks were found in breast cancer tissues by SR-FTIR spectroscopic methods. These spectral characteristics of breast tissue may help us in early diagnosis of breast cancer. C 2006 Elsevier B.V. All rights reserved Keywords: FTIR spectroscopy: Synchrotron radiation: Breast cancer Introduction disease has become more popular in China leading to great suffering for women. In the latest 5 years Breast cancer is a global killer of women. in China, the incidence of breast cancer per year Previously this cancer mainly occurred in the has increased almost three times, from 17 out of western countries, but in recent years, this frightful 100.000 52 out of 100.000. while the mean starting age of this cancer in China is 30 years old Corresponding author. Department of Physics, Surtace with its peak age from 40 to 49, which is 10-15 Radiation Research Center, Fudan University, Shanghai years earlier than in the US [1]. Unfortunately, 200433 China. Tel /fax: because of the late treatment, a part of patients, E-mailaddress:xy.zhang@fudan.edu.cn(X.Zhang) which is as high as about 35% in China, are 0022-2313/S-see front matter C 2006 Elsevier B.v. All rights reserved i:l0.l016 jalumin2005.12.050Journal of Luminescence 119–120 (2006) 132–136 Infrared absorption of human breast tissues in vitro Chenglin Liua,b, Yuan Zhanga , Xiaohui Yana , Xinyi Zhanga,c,
, Chengxiang Lid , Wentao Yange , Daren Shie a Department of Physics, Surface Physics Laboratory (National Key laboratory), Synchrotron Radiation Research Center, Fudan University, Shanghai 200433, China b Physics Department of Yancheng Teachers’ College, Yancheng 224002, China c Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203, China d National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China e Cancer Hospital, Medical Center, Fudan University, Shanghai 200032, China Available online 7 February 2006 Abstract The spectral characteristics of human breast tissues in normal status and during different cancerous stages have been investigated by synchrotron radiation based Fourier transform infrared (SR–FTIR) absorption spectroscopy. Thanks to the excellent synchrotron radiation infrared (IR) source, higher resolving power is achieved in SR–FTIR absorption spectra than in conventional IR absorption measurements. Obvious variations in IR absorption spectrum of breast tissues were found as they change from healthy to diseased, or say in progression to cancer. On the other hand, some specific absorption peaks were found in breast cancer tissues by SR–FTIR spectroscopic methods. These spectral characteristics of breast tissue may help us in early diagnosis of breast cancer. r 2006 Elsevier B.V. All rights reserved. Keywords: FTIR spectroscopy; Synchrotron radiation; Breast cancer 1. Introduction Breast cancer is a global killer of women. Previously this cancer mainly occurred in the western countries, but in recent years, this frightful disease has become more popular in China leading to great suffering for women. In the latest 5 years in China, the incidence of breast cancer per year has increased almost three times, from 17 out of 100,000 to 52 out of 100,000, while the mean starting age of this cancer in China is 30 years old with its peak age from 40 to 49, which is 10–15 years earlier than in the US [1]. Unfortunately, because of the late treatment, a part of patients, which is as high as about 35% in China, are ARTICLE IN PRESS www.elsevier.com/locate/jlumin 0022-2313/$ - see front matter r 2006 Elsevier B.V. All rights reserved. doi:10.1016/j.jlumin.2005.12.050
Corresponding author. Department of Physics, Surface Physics Laboratory (National Key laboratory), Synchrotron Radiation Research Center, Fudan University, Shanghai 200433, China. Tel.:/fax: +86 21 65643522. E-mail address: xy-zhang@fudan.edu.cn (X. Zhang)