白血病染色体易位 ALL AML 30% AMLt电 t821) 12% MYc BCR-ABL 7q35TCRB P98-HQXA9 14011/TCRao MYC /29 CBFD-MYH11 t8;14)t(28)822) inv(18) 1% FUS-ERG 20% MLL-AF9 E2A-PBX1 TELAML1 1%t1621) t81) t(1: 19) E2A-HLF t12:21 PML-RARa DEK-CAN 图7v) MLL fusio t17:10)t:111:11+41 t15;17)t1:17 NPM-MLF1 t5:17) Bcel Pro-B cell 口 Promyelocytic口 Myelodysplastic, diverse myel Most of the fusion genes involved in AL translocations are transcription factors(TFs): abnormalities in lineage commitment and differentiation Look AT Science. 278: 1059Look AT. Science, 278: 1059 白血病染色体易位 Most of the fusion genes involved in AL translocations are transcription factors (TFs): abnormalities in lineage commitment and differentiation