Progression The expression of malignant phenotype, the tendency to acquire more aggressive characteristics. metastasis Propensity for genomic instability and uncontrolled growth Further genetic changes: the activation of proto- oncogenes and the inactivation of tumor- suppressor genes16 Progression • The expression of malignant phenotype, the tendency to acquire more aggressive characteristics, Metastasis • Propensity for genomic instability and uncontrolled growth • Further genetic changes: the activation of proto￾oncogenes and the inactivation of tumor￾suppressor genes