Disadvantages of Tablets Swallowing:Children and comatose patients may not swallow tablets Volatile components in tablets may be lost during the long periods of storage Formulation difficulties: Some drugs have poor oral bioavailability or poor water solubility Some drugs have an irritant effect on the GI tract when taken orallyDisadvantages of Tablets • Swallowing:Children and comatose patients may not swallow tablets • Volatile components in tablets may be lost during the long periods of storage • Formulation difficulties: • Some drugs have poor oral bioavailability or poor water solubility • Some drugs have an irritant effect on the GI tract when taken orally