Mechanism Bone physiology a The bone is continuously remodelling, and the bone surface moves in and out. The Basic Multicellular Unit (BMU)is a wandering team of cells that dissolves an area of the bone surface and then fills it with new bone. the sequence is Origination, Osteoclast recruitment, Resorption, Osteoblast recruitment osteoid formation mineralization mineral maturation. Quiescence w Bone strength(Quality): In addition to bone porosity, the bone strength is determined by the trabecular microstructure Perforations of individual trabecula occur when resorption cavities are too deep. This, too, is seen with estrogen deficiency. The remaining trabecula are not as well connected and are mechanically weakerMechanism : Bone physiology  The bone is continuously remodelling, and the bone surface moves in and out. The Basic Multicellular Unit (BMU) is a wandering team of cells that dissolves an area of the bone surface and then fills it with new bone. The sequence is Origination, Osteoclast recruitment, Resorption, Osteoblast recruitment, Osteoid formation, Mineralization, Mineral maturation, Quiescence.  Bone strength (Quality): In addition to bone porosity, the bone strength is determined by the trabecular microstructure. Perforations of individual trabecula occur when resorption cavities are too deep. This, too, is seen with estrogen deficiency. The remaining trabecula are not as well connected and are mechanically weaker