Thyroid hormone synthesis and metabolism The thyroid follicle is stimulated by tsh by increase with TSH receptor Iodine from the circulation is concentrated and rapidly oxidized by peroxidase to iodine Iodine incorporated into tyrosyl residures on thyroglobulin Iodothyrosines are couple an ether linkage to form T4 and T3Thyroid hormone synthesis and metabolism • The thyroid follicle is stimulated by TSH by increase with TSH receptor • Iodine from the circulation is concentrated and rapidly oxidized by peroxidase to iodine • Iodine incorporated into tyrosyl residures on thyroglobuline • Iodothyrosines are couple an ether linkage to form T4 and T3