黄晓丽,等.普拉梭菌与肠道疾病关系的研究进展 ■名词斛释 products of Fusobacterium prausnitzii, and a Louis P. Effect of inulin on the human 微生态失衡;肠道 proposal to reclassify it as Faecalibacterium iota, stimulation of bifidobacterium 菌群素乱指人体 肠道内致病菌和 comb. nov. Int) Syst Evol and Faecalibacterium prausnitz. Br Microbiol2002;52:2141-2146[PMID:12508881 101:541-550[PMD:18590586DO 益生菌的比例失 DO:10.1099/00207713-52-6-214 10.1017/50007114508019880 调致病菌、条件6 Hold GL, Schwiertz A, Aminov ri, Blaut m,16 Carlsson ah, Yakymenko c, Olivier I 致病菌的数量增 多,而益生菌数量 Flint HJ. Oligonucleotide probes that detect Hakansson F, Postma E, Keita AV, Soderholm JD. quantitatively significant groups of butyrate- Faecalbacterium prausnitzii supernatant improve 肠黏膜屏障:指肠 producing bacteria in human feces. Appl Environ intestinal barrier function in mice dss colitis. Saund Microbio200369:4320-4324[PMD:12839823 J Gastroenterol 2013 48: 1136-1144 [PMID: 23971882 的有害物质如细7 Nava GM, Tappenbeck TS. Diversity of the DOL10.3109/003655212013.828773 菌和毒素穿过肠 utochthonous colonic microbiota Gut Microbes 17 Laval L, Martin R, Natividad JN, Chain F, 黏膜进入人体内 其他组织、器官8 Oikonomou g, Teixeira AG, Foditsch C S, Sokol H, Verdu EF, van Hylckama Vlieg JE, 和血液循环的结 Bicalho ML, Machado vs, Bicalho RC. Fecal Bermudez-Humaran LG, Smokvina T, Langella 构和功能的总和 microbial diversity in pre-weaned dairy calves P. Lactobacillus rhamnosus CNCM 1-3690 and the commensal bacterium Faecalibacteriu 16s rDNA. Associations of Faecalibacterium prausnitzii A2-165 exhibit similar protective species with health and growth. PLos One 2013: effects to induced barrier hyper-permeability in 8:e63157[PMID:23646192DO:101371/ journal mice. Gut Microbes 2015: 6: 1-9 [PMID: 25517879 pone.0063157 DOI10.4161/194909762014990784 9 Lopez-Siles M, Khan TM, Duncan SH, 18 Louis P, Flint HJ. Diversity, metabolism and Harmsen H, Garcia-Gil LJ, Flint H. Cultured microbial ecology of butyrate-producing bacteri from the human large intestine. FEMS Microbi human colonic Faecalibacterium prausnitzii can et2009294:1-8[PMD:1922573DO:10.11 utilize pectin, cids, and host-derive 1574-6968200901514x] ubstrates for Appl Environ Microbiol 19 Rossi O, Khan MT, Schwarzer M, Hudcovic T 201278:420428PMID:22101049DO:10.1128/ utkova D. duncan sh Stolte eh, Kozakova AEM06858-11 H, Flint H, Samsom JN, Harmsen H, Wells JM. 10 Benus RF, van der Werf TS, Welling Gw Faecalibacterium prausnitzii Strain HTF-F and Judd PA, Taylor MA, Harmsen HJ, Whelan K Its Extracellular Polymeric Matrix Attenuate Association between Faecalibacterium prausnitz Clinical Parameters in DSS-Induced Colitis. PLos and dietary fibre in colonic fermentation One2015;10:e0123013PMID:25910186DOl: in healthy human subjects. Br) Nutr 2010 104: 693-700 [PMID: 20346190 DOI: 10.1017/ 20 Miquel S, Leclerc M, Martin R, Chain E, Lenoir M, 0007114510001030 Raguideau S, Hudault S, Bridonneau C, Northen 11 DOrffel Y, Swidsinski A, Loening-Baucke V T, Bowen B, Bermudez-Humaran LG, Sokol H Wiedenmann B, Pavel M. Common biostructure Thomas M, Langella P. Identification of metabolic of the colonic microbiota signatures linked to anti-inflammatory effects tumors and Crohn's disease and the effect of of Faecalibacterium prausnitzii MBio 2015; 6 therapy. Inflamm Bowel Dis 2012; 18: 1663-1671 e00300-15[PMID:25900655DOI:10.1128/ [PMD2213988DO:10.1002/ibd21923 12 Swidsinski A, Loening-Baucke V, Vaneechoutte 21 Quevrain E, Maubert MA, Michon C, Chain F, M, Doerffel Y. Active Crohn's disease and R, Tailhades J lel S, Carlier L, and monitored based on the biostructure of the O, Kharrat P, Thomas G, Rainteau D, Aubry fecal flora. Inflamm Bowel Dis 2008: 14: 147-161 N Afonso c lavelle s, grill PMD:18050295DOl:10.1002/ibd.20330 Chassaing G, Chatel JM, Trugnan G, Xavier R, 13 Li E, Hamm CM, Gulati As, Sartor RB, Chen Langella P, Sokol H, Seksik P. Identification of an H, Wu X, Zhang T, Rohlf FJ, Zhu W, Gu C, anti-inflammatory protein from Faecalibacterium Robertson CE, Pace NR, Boedeker EC, Harpaz prausnitzii, a commensal bacterium deficient in N, Yuan J, Weinstock GM, Sodergren E, Frank Crohns disease. Gut 2016; 65: 415-425 [PMID DN. Inflammatory bowel diseases phenotype, 26045134DOL10.1136/ guting-2014-307649 C difficile and NOD2 genotype ssociated 22 Martinez-Medina M, Aldeguer X, Gonzalez-Huix with shifts in human ileum associated microbial F, Acero D, Garcia-Gil L. Abnormal microbiota omposition. PLos One 2012; 7: e26284 [PMID: omposition in the ileocolonic mucosa of Crohn 22719818DO:10.1371/ journal. pone:0026284 s disease patients as revealed by polymerase chain 14 Rossi O, van Berkel LA, Chain F, Tanweer Khan reaction-denaturing gradient gel electrophoresis M. Taverne n sokol h duncan sh Flint h am Bowel Dis 2006; 12: 1136-1145 [PMID: Harmsen H, Langella P, Samsom JN, Wells JM. 17119388DOl:10.1097/01mib00003582809050 Faecalibacterium prausnitzii A2-165 has a high 23 Machiels K, Joossens M, Sabino J, De Preter apacity to induce IL-10 in human and murine V, Arijs I, Eeckhaut V, Ballet V, Claes K, va dendritic cells and modulates T cell responses. Sci Immerseel F, Verbeke K, Ferrante M, Verhaegen p20166:18507PMID26725514DO:10.1038/ J, Rutgeerts P, Vermeire S. A decrease of the utvrat 15 Ramirez-Farias C Slezak K Fuller Z Duncan A, and Faecalibacterium prausnitzii defines . 5Aishideng 814 2017-03-28I Volume 25 Issue 9 I黄晓丽, 等. 普拉梭菌与肠道疾病关系的研究进展 WCJD|www.wjgnet.com 814 2017-03-28|Volume 25|Issue 9| products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov. Int J Syst Evol Microbiol 2002; 52: 2141-2146 [PMID: 12508881 DOI: 10.1099/00207713-52-6-2141] 6 Hold GL, Schwiertz A, Aminov RI, Blaut M, Flint HJ. Oligonucleotide probes that detect quantitatively significant groups of butyrate￾producing bacteria in human feces. Appl Environ Microbiol 2003; 69: 4320-4324 [PMID: 12839823] 7 Nava GM, Stappenbeck TS. Diversity of the autochthonous colonic microbiota. Gut Microbes 2011; 2: [PMID: 21637026] 8 Oikonomou G, Teixeira AG, Foditsch C, Bicalho ML, Machado VS, Bicalho RC. Fecal microbial diversity in pre-weaned dairy calves as described by pyrosequencing of metagenomic 16S rDNA. Associations of Faecalibacterium species with health and growth. PLoS One 2013; 8: e63157 [PMID: 23646192 DOI: 10.1371/journal. pone.0063157] 9 L o p e z - S i l e s M , K h a n T M , D u n c a n S H , Harmsen HJ, Garcia-Gil LJ, Flint HJ. Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth. Appl Environ Microbiol 2012; 78: 420-428 [PMID: 22101049 DOI: 10.1128/ AEM.06858-11] 10 Benus RF, van der Werf TS, Welling GW, Judd PA, Taylor MA, Harmsen HJ, Whelan K. Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects. Br J Nutr 2010; 104: 693-700 [PMID: 20346190 DOI: 10.1017/ S0007114510001030] 11 Dörffel Y, Swidsinski A, Loening-Baucke V, Wiedenmann B, Pavel M. Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn’s disease and the effect of therapy. Inflamm Bowel Dis 2012; 18: 1663-1671 [PMID: 22113988 DOI: 10.1002/ibd.21923] 12 Swidsinski A, Loening-Baucke V, Vaneechoutte M, Doerffel Y. Active Crohn’s disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora. Inflamm Bowel Dis 2008; 14: 147-161 [PMID: 18050295 DOI: 10.1002/ibd.20330] 13 Li E, Hamm CM, Gulati AS, Sartor RB, Chen H, Wu X, Zhang T, Rohlf FJ, Zhu W, Gu C, Robertson CE, Pace NR, Boedeker EC, Harpaz N, Yuan J, Weinstock GM, Sodergren E, Frank DN. Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition. PLoS One 2012; 7: e26284 [PMID: 22719818 DOI: 10.1371/journal.pone.0026284] 14 Rossi O, van Berkel LA, Chain F, Tanweer Khan M, Taverne N, Sokol H, Duncan SH, Flint HJ, Harmsen HJ, Langella P, Samsom JN, Wells JM. Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses. Sci Rep 2016; 6: 18507 [PMID: 26725514 DOI: 10.1038/ srep18507] 15 Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P. Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr 2009; 101: 541-550 [PMID: 18590586 DOI: 10.1017/S0007114508019880] 16 C a r l s s o n A H , Y a k y m e n k o O , O l i v i e r I , Håkansson F, Postma E, Keita AV, Söderholm JD. Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis. Scand J Gastroenterol 2013; 48: 1136-1144 [PMID: 23971882 DOI: 10.3109/00365521.2013.828773] 17 Laval L, Martin R, Natividad JN, Chain F, Miquel S, Desclée de Maredsous C, Capronnier S, Sokol H, Verdu EF, van Hylckama Vlieg JE, Bermúdez-Humarán LG, Smokvina T, Langella P. Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice. Gut Microbes 2015; 6: 1-9 [PMID: 25517879 DOI: 10.4161/19490976.2014.990784] 18 Louis P, Flint HJ. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett 2009; 294: 1-8 [PMID: 19222573 DOI: 10.1111/ j.1574-6968.2009.01514.x] 19 Rossi O, Khan MT, Schwarzer M, Hudcovic T, Srutkova D, Duncan SH, Stolte EH, Kozakova H, Flint HJ, Samsom JN, Harmsen HJ, Wells JM. Faecalibacterium prausnitzii Strain HTF-F and Its Extracellular Polymeric Matrix Attenuate Clinical Parameters in DSS-Induced Colitis. PLoS One 2015; 10: e0123013 [PMID: 25910186 DOI: 10.1371/journal.pone.0123013] 20 Miquel S, Leclerc M, Martin R, Chain F, Lenoir M, Raguideau S, Hudault S, Bridonneau C, Northen T, Bowen B, Bermúdez-Humarán LG, Sokol H, Thomas M, Langella P. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii. MBio 2015; 6: pii e00300-15 [PMID: 25900655 DOI: 10.1128/ mBio.00300-15] 21 Quévrain E, Maubert MA, Michon C, Chain F, Marquant R, Tailhades J, Miquel S, Carlier L, Bermúdez-Humarán LG, Pigneur B, Lequin O, Kharrat P, Thomas G, Rainteau D, Aubry C, Breyner N, Afonso C, Lavielle S, Grill JP, Chassaing G, Chatel JM, Trugnan G, Xavier R, Langella P, Sokol H, Seksik P. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease. Gut 2016; 65: 415-425 [PMID: 26045134 DOI: 10.1136/gutjnl-2014-307649] 22 Martinez-Medina M, Aldeguer X, Gonzalez-Huix F, Acero D, Garcia-Gil LJ. Abnormal microbiota composition in the ileocolonic mucosa of Crohn’ s disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis. Inflamm Bowel Dis 2006; 12: 1136-1145 [PMID: 17119388 DOI: 10.1097/01.mib.0000235828.09305.0c] 23 Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, Eeckhaut V, Ballet V, Claes K, Van Immerseel F, Verbeke K, Ferrante M, Verhaegen J, Rutgeerts P, Vermeire S. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines ■名词解释 微生态失衡: 肠道 菌群紊乱, 指人体 肠道内致病菌和 益生菌的比例失 调, 致病菌、条件 致病菌的数量增 多, 而益生菌数量 减少; 肠黏膜屏障: 指肠 道能够防止肠内 的有害物质如细 菌和毒素穿过肠 黏膜进入人体内 其他组织、器官 和血液循环的结 构和功能的总和