Forms of cell signaling (A) Hormones produced in endocrine glands are secreted into the bloodstream and can be distributed widely throughout the bod (B) Paracrine signals are released by cells into the extracellular medium in their neighborhood and act locally (C) Neuronal signals are transmitted along axons to remote target cells (D) Contact-dependent signaling requires cells to be in direct membrane-to-membrane contact with each other (especially during development and immune responsesForms of cell signaling (A) Hormones produced in endocrine glands are secreted into the bloodstream and can be distributed widely throughout the body. (B) Paracrine signals are released by cells into the extracellular medium in their neighborhood and act locally. (C) Neuronal signals are transmitted along axons to remote target cells. (D) Contact-dependent signaling requires cells to be in direct membrane-to-membrane contact with each other. (especially during development and immune responses)