Pharmacokinetics Drug disposition ADME ·Absorption ·Distribution Metabolism(biotransformation) ·Excretion Quantification of drug concentration in the body,and mathematic modeling ADME of a drug taken orally Oral administration Blood Bound drug Gut_ Absorption Free drug Metabolite Excretion Urine Target organ LiverPharmacokinetics • Drug disposition = ADME • Absorption • Distribution • Metabolism (biotransformation) • Excretion • Quantification of drug concentration in the body, and mathematic modeling ADME of a drug taken orally