Reduction of effective △ rterial Volume a key element of these responses Salt and water retention by renal proximal tubule If the retention of salt and water is insufficient to restore and maintain the effective arterial blood the stimuli are not dissipated, the retention of salt and water continues, the edema may ultimately develop Operative in dehydration and hemorrhageReduction of Effective Arterial Volume • A key element of these responses Salt and water retention by renal proximal tubule • If the retention of salt and water is insufficient to restore and maintain the effective arterial blood, the stimuli are not dissipated, the retention of salt and water continues, the edema may ultimately develop • Operative in dehydration and hemorrhage