Medical Genetics The advantage of microsatellites over minisatellites is that the size of each allele is much smaller and they are therefore more amenable to PCR analysis. Their small size also means that they are more likely to remain intact in highly degraded DNA such as that from forensic samples or from ancient dna - for example from Egyptian mummiesMedical Genetics The advantage of microsatellites over minisatellites is that the size of each allele is much smaller and they are therefore more amenable to PCR analysis. Their small size also means that they are more likely to remain intact in highly degraded DNA such as that from forensic samples or from ancient DNA - for example from Egyptian mummies