BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Chemistry of biodegradable solid polymers Pathways of solid polymer erosion (SLIDE) I5 BIOaF SORRARTE AND BEOFRDDO L MATIHIALY Used fo biodegradable hydrogels Main mechanism exploited in solid (Ratner, Biomaterials Science) Example Materials- Common hydrolytically unstable linkages Mechanism Crosslinked polyanhydrides buffer solution ∞ 人+ p=3 MCPP P=6 MCPH Lecture 1-IntroductionBEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Chemistry of biodegradable solid polymers Pathways of solid polymer erosion (SLIDE) Used for biodegradable I hydrogels II Main mechanism exploited in solid III polymers (Ratner, Biomaterials Science) Example Materials- Common hydrolytically unstable linkages: Mechanism I: Crosslinked polyanhydrides5-7: Lecture 1 – Introduction