病的细爬机制 Cyclins降解主要是泛素-蛋白酶体进行泛素化降解 (b)Polyubiquitination of mitotic cycli APC (E3) Proteasome cyclin peptides n E2 Mitotic cyclin destruction box n E1 COOH n El-Q Cyclin A Arg-Thr-Val-Leu-Gly-Val--lle-Gly-Asp Ubiquitin Cyclin B1 Arg-Thr-Ala-Leu-Gly-Asp-lle-Gly-Asn Cyclin B2 Arg-Ala-Ala-Leu-Gly-Glu-Hle-Gly-Asn 1002组成 cyclin oox Cyclin H2N COOH cyclin Combine) CDK CDK 催化亚基 Cyclin/CDKCyclins降解主要是泛素-蛋白酶体进行泛素化降解 疾病的细胞机制 100aa组成cyclin box Cyclin H2N- -COOH cyclin CDK Cyclin/CDK Combine 催化亚基 CDK