Systemic edema Nephrotic Syndrome/ Hypoalbuminemic states The primary alteration: decreased colloid oncotic pressure protein loss in the urine severe nutritional deficiency protein loss enteropathy congentital hypoalbuminemia Iver cirrhosis Promotes fluid move into the interstitium Causes hypovolemia salt/water retention activation RAA axis etcSystemic edema Nephrotic Syndrome/ Hypoalbuminemic states • The primary alteration: decreased colloid oncotic pressure protein loss in the urine severe nutritional deficiency protein loss enteropathy congentital hypoalbuminemia liver cirrhosis • Promotes fluid move into the interstitium • Causes hypovolemia salt/water retention activation RAA axis etc