5.3 Synthetic antifungalAgents 5.3.1 Azoles R N-(CH2)n-C-R2 XEN. CH r Beginning in the late of 1960s, an extensive series of azole compounds have been synthesized and tested for antifungal activity. Currently, the the r&d for antifungal agents are also focused on this sacffold The mechanism of action ofazole: Inhibition of cytochrome P-450 that catalyzes 14-apha demethylation of lanosterol to ergosterol. accumulation of 14 methylated sterol cause permeability disrution5.3 Synthetic antifungal Agents 5.3.1 Azoles Beginning in the late of 1960s,an extensive series of azole compounds have been synthesized and tested for antifungal activity.Currently, the the R&D for antifungal agents are also focused on this sacffold. The mechanism of action of azole : Inhibition of cytochrome P-450 that catalyzes 14-apha￾demethylation of lanosterol to ergosterol,accumulation of 14- methylated sterola cause permeability disrution. N X N (CH2 )n C R1 R2 Ar n= X=N, CH 0 , 1