Immature B Cells Interaction of self molecules and immature B cells is important in development of "se/f-tolerance"in the bone marrow B cells with potential reactivity to self are prevented from responding "negative selection" Deletion (apoptosis) Anergy (inactivation) Self reactive B cells may also undergo receptor editing"to generate a new(foreign)specificity "rescued"from inactivationImmature B Cells ◼ Interaction of self molecules and immature B cells is important in development of “self-tolerance” in the bone marrow ◼ B cells with potential reactivity to self are prevented from responding → “negative selection” ◼ Deletion (apoptosis) ◼ Anergy (inactivation) ◼ Self reactive B cells may also undergo “receptor editing” to generate a new (foreign) specificity ◼ “rescued” from inactivation